Beta-hCG Rule of 10s

Describes the general pattern of βhCG during pregnancy in humans.

βhCG levels:

  • 10 u at first missed menses
  • 100 000 u at 10 weeks (highest value)
  • 10 000 at delivery

Levels double every 1-2 days for the first 8-10 weeks, then drop off and plateau before delivery

Levels higher than expected:

  • wrong dates
  • multiple gestation
  • molar pregnancy
  • Trisomy 21

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